Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3405552..3406172 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N5927_RS16750 Protein ID WP_001280991.1
Coordinates 3405954..3406172 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N5927_RS16745 Protein ID WP_000344807.1
Coordinates 3405552..3405926 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS16735 (3400691) 3400691..3401884 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5927_RS16740 (3401907) 3401907..3405056 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N5927_RS16745 (3405552) 3405552..3405926 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N5927_RS16750 (3405954) 3405954..3406172 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N5927_RS16755 (3406351) 3406351..3406902 + 552 WP_001278793.1 maltose O-acetyltransferase -
N5927_RS16760 (3407020) 3407020..3407490 + 471 WP_000136183.1 YlaC family protein -
N5927_RS16765 (3407546) 3407546..3407686 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N5927_RS16770 (3407692) 3407692..3407952 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N5927_RS16775 (3408177) 3408177..3409727 + 1551 WP_000213140.1 EAL domain-containing protein -
N5927_RS16785 (3409958) 3409958..3410347 + 390 WP_000961287.1 MGMT family protein -
N5927_RS16790 (3410380) 3410380..3410949 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258749 WP_001280991.1 NZ_CP104641:3405954-3406172 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258749 WP_000344807.1 NZ_CP104641:3405552-3405926 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References