Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5033670..5034141 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag N4555_RS24900 Protein ID WP_001303511.1
Coordinates 5033863..5034141 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag N4555_RS24895 Protein ID WP_001302048.1
Coordinates 5033670..5033861 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS24855 (5028877) 5028877..5029461 - 585 WP_000206793.1 DUF551 domain-containing protein -
N4555_RS24860 (5029518) 5029518..5029913 - 396 WP_001118159.1 DUF977 family protein -
N4555_RS24865 (5029929) 5029929..5030698 - 770 Protein_4846 DUF1627 domain-containing protein -
N4555_RS24870 (5030724) 5030724..5031464 - 741 WP_000788938.1 ATP-binding protein -
N4555_RS24875 (5031471) 5031471..5032433 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
N4555_RS24880 (5032456) 5032456..5032881 - 426 WP_000693943.1 toxin YdaT family protein -
N4555_RS24885 (5032878) 5032878..5033180 - 303 WP_000172738.1 transcriptional regulator -
N4555_RS24890 (5033278) 5033278..5033649 + 372 WP_001169686.1 hypothetical protein -
N4555_RS24895 (5033670) 5033670..5033861 + 192 WP_001302048.1 hypothetical protein Antitoxin
N4555_RS24900 (5033863) 5033863..5034141 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4555_RS24905 (5034494) 5034494..5034793 + 300 WP_001240334.1 hypothetical protein -
N4555_RS24910 (5034865) 5034865..5035083 + 219 WP_001171930.1 protein YdfC -
N4555_RS24915 (5035652) 5035652..5035840 + 189 WP_000449192.1 cell division inhibition protein DicB -
N4555_RS24920 (5035837) 5035837..5036028 + 192 WP_001090200.1 DUF1482 family protein -
N4555_RS24925 (5036121) 5036121..5038592 + 2472 WP_000048458.1 exonuclease -
N4555_RS24930 (5038665) 5038665..5038916 + 252 WP_000005552.1 excisionase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4991746..5049021 57275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T258731 WP_001303511.1 NZ_CP104639:5033863-5034141 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT258731 WP_001302048.1 NZ_CP104639:5033670-5033861 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References