Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4859897..4860535 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N4555_RS24040 Protein ID WP_000813794.1
Coordinates 4859897..4860073 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4555_RS24045 Protein ID WP_001270286.1
Coordinates 4860119..4860535 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS24020 (4855519) 4855519..4856691 - 1173 WP_001236316.1 BenE family transporter YdcO -
N4555_RS24025 (4856783) 4856783..4857319 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
N4555_RS24030 (4857392) 4857392..4859353 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N4555_RS24035 (4859445) 4859445..4859675 - 231 WP_000494244.1 YncJ family protein -
N4555_RS24040 (4859897) 4859897..4860073 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N4555_RS24045 (4860119) 4860119..4860535 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N4555_RS24050 (4860614) 4860614..4862020 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
N4555_RS24055 (4862265) 4862265..4863410 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
N4555_RS24060 (4863428) 4863428..4864441 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
N4555_RS24065 (4864442) 4864442..4865383 + 942 WP_001251320.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258730 WP_000813794.1 NZ_CP104639:4859897-4860073 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258730 WP_001270286.1 NZ_CP104639:4860119-4860535 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References