Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3789010..3789715 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag N4555_RS18080 Protein ID WP_000539519.1
Coordinates 3789329..3789715 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N4555_RS18075 Protein ID WP_001280945.1
Coordinates 3789010..3789339 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS18060 (3784167) 3784167..3785078 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
N4555_RS18065 (3785256) 3785256..3787604 + 2349 WP_000950320.1 EAL domain-containing protein -
N4555_RS18070 (3787612) 3787612..3788940 + 1329 WP_000086905.1 GGDEF domain-containing protein -
N4555_RS18075 (3789010) 3789010..3789339 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N4555_RS18080 (3789329) 3789329..3789715 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4555_RS18085 (3789941) 3789941..3791266 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N4555_RS18090 (3791479) 3791479..3791862 + 384 WP_000497137.1 biofilm formation regulator BssR -
N4555_RS18095 (3791973) 3791973..3793088 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
N4555_RS18100 (3793085) 3793085..3793711 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T258724 WP_000539519.1 NZ_CP104639:c3789715-3789329 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT258724 WP_001280945.1 NZ_CP104639:c3789339-3789010 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References