Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3334406..3335024 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4555_RS15990 Protein ID WP_001291435.1
Coordinates 3334406..3334624 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4555_RS15995 Protein ID WP_000344800.1
Coordinates 3334650..3335024 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS15955 (3329693) 3329693..3330265 + 573 WP_000779831.1 YbaY family lipoprotein -
N4555_RS15960 (3330298) 3330298..3330609 - 312 WP_000409911.1 MGMT family protein -
N4555_RS15970 (3330988) 3330988..3331341 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N4555_RS15975 (3331383) 3331383..3332933 - 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4555_RS15980 (3333097) 3333097..3333567 - 471 WP_000136192.1 YlaC family protein -
N4555_RS15985 (3333683) 3333683..3334234 - 552 WP_000102553.1 maltose O-acetyltransferase -
N4555_RS15990 (3334406) 3334406..3334624 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N4555_RS15995 (3334650) 3334650..3335024 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4555_RS16000 (3335570) 3335570..3338719 - 3150 WP_001132452.1 efflux RND transporter permease AcrB -
N4555_RS16005 (3338742) 3338742..3339935 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258723 WP_001291435.1 NZ_CP104639:c3334624-3334406 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258723 WP_000344800.1 NZ_CP104639:c3335024-3334650 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References