Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2843313..2843863 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag N4555_RS13695 Protein ID WP_001160975.1
Coordinates 2843549..2843863 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag N4555_RS13690 Protein ID WP_000125566.1
Coordinates 2843313..2843546 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS13665 (2838387) 2838387..2838674 + 288 WP_000203741.1 ferredoxin-like protein FixX -
N4555_RS13670 (2838732) 2838732..2840063 + 1332 WP_001183177.1 MFS transporter -
N4555_RS13675 (2840171) 2840171..2840701 + 531 WP_000600700.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
N4555_RS13680 (2840694) 2840694..2842556 + 1863 WP_000377184.1 glutathione-regulated potassium-efflux system protein KefC -
N4555_RS13685 (2842748) 2842748..2843227 + 480 WP_000624372.1 type 3 dihydrofolate reductase -
N4555_RS13690 (2843313) 2843313..2843546 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N4555_RS13695 (2843549) 2843549..2843863 + 315 WP_001160975.1 CcdB family protein Toxin
N4555_RS13700 (2843860) 2843860..2844708 - 849 WP_000257187.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
N4555_RS13705 (2844715) 2844715..2845092 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
N4555_RS13710 (2845095) 2845095..2845916 - 822 WP_001065380.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
N4555_RS13715 (2845913) 2845913..2846902 - 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
N4555_RS13720 (2846902) 2846902..2848188 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T258721 WP_001160975.1 NZ_CP104639:2843549-2843863 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT258721 WP_000125566.1 NZ_CP104639:2843313-2843546 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References