Detailed information of TA system TA025872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 137954..138437
• Replicon: chromosome
• Accession: NC_016802
• Organism: Corynebacterium diphtheriae HC02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A806GHY4
• Locus tag: CDHC02_RS00755
• Protein ID: WP_014302726.1
• Coordinates: 138174..138437 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CDHC02_RS00750
• Protein ID: WP_003850117.1
• Coordinates: 137954..138190 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDHC02_RS00720	133301..133765	+	465	WP_014318641.1	hypothetical protein	-
CDHC02_RS11620	133874..134125	+	252	WP_014319663.1	hypothetical protein	-
CDHC02_RS11625	134143..134442	+	300	WP_044035346.1	hypothetical protein	-
CDHC02_RS00730	134447..134707	+	261	WP_014307785.1	hypothetical protein	-
CDHC02_RS00735	135565..135951	+	387	WP_041630967.1	hypothetical protein	-
CDHC02_RS00740	135959..136849	+	891	WP_014307788.1	hypothetical protein	-
CDHC02_RS00745	136896..137579	-	684	WP_014307789.1	hypothetical protein	-
CDHC02_RS00750	137954..138190	+	237	WP_003850117.1	ribbon-helix-helix domain-containing protein	Antitoxin
CDHC02_RS00755	138174..138437	+	264	WP_014302726.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDHC02_RS00760	138564..138857	+	294	WP_003850121.1	RNA-binding S4 domain-containing protein	-
CDHC02_RS00765	138857..139681	+	825	WP_014301205.1	VOC family protein	-
CDHC02_RS00770	139687..139992	+	306	WP_003850125.1	MGMT family protein	-
CDHC02_RS00775	140002..140922	-	921	WP_014319664.1	alpha/beta hydrolase	-
CDHC02_RS00780	141062..141688	+	627	WP_014302728.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	99729..138857	39128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (7-43)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9911.45 Da
• Isoelectric Point: 10.9201

>T25872 WP_014302726.1 NC_016802:138174-138437 [Corynebacterium diphtheriae HC02]
VAWEISFSPRAVKSFKKLDTGEQRRVSKFLREVGALEDPRLRGKALTANKSGLWRWRVGDYRIIADIVDARVVVVVVDVG
HRSKAYD

Nucleotide

• Length: 264 bp

>T25872 NC_016802:138174-138437 [Corynebacterium diphtheriae HC02]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGCGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGCCTACGACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8911.02 Da
• Isoelectric Point: 4.8604

>AT25872 WP_003850117.1 NC_016802:137954-138190 [Corynebacterium diphtheriae HC02]
MSGSVISLRIDDEQKRRLDELSRRTGRPCSFYLREALSAHLADLEYVYRLEEEAAQVRRGELGTVPLSQLERECGLGD

Nucleotide

• Length: 237 bp

>AT25872 NC_016802:137954-138190 [Corynebacterium diphtheriae HC02]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGCGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Structures

Toxin

• AlphaFold DB: A0A806GHY4