Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1689593..1690224 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name hicA Uniprot ID Q8X5S6
Locus tag N4555_RS08410 Protein ID WP_001259386.1
Coordinates 1689949..1690224 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N4555_RS08405 Protein ID WP_000593555.1
Coordinates 1689593..1689952 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS08375 (1684705) 1684705..1685178 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
N4555_RS08380 (1685175) 1685175..1685456 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
N4555_RS08385 (1685533) 1685533..1686891 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
N4555_RS08390 (1686884) 1686884..1688392 + 1509 WP_001301773.1 FGGY-family carbohydrate kinase -
N4555_RS08395 (1688382) 1688382..1688651 + 270 WP_000933060.1 HPr family phosphocarrier protein -
N4555_RS08400 (1688683) 1688683..1689543 + 861 WP_001131788.1 class II aldolase -
N4555_RS08405 (1689593) 1689593..1689952 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4555_RS08410 (1689949) 1689949..1690224 - 276 WP_001259386.1 type II toxin-antitoxin system HicA family toxin Toxin
N4555_RS08415 (1690297) 1690297..1691421 - 1125 WP_001301659.1 ABC transporter permease -
N4555_RS08420 (1691421) 1691421..1694156 - 2736 WP_000149107.1 ribosome-associated ATPase/putative transporter RbbA -
N4555_RS08425 (1694153) 1694153..1695220 - 1068 WP_000361458.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10165.92 Da        Isoelectric Point: 10.7076

>T258716 WP_001259386.1 NZ_CP104639:c1690224-1689949 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKLILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258716 WP_000593555.1 NZ_CP104639:c1689952-1689593 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9WXY7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References