Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1598138..1598892 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag N4555_RS07950 Protein ID WP_001301452.1
Coordinates 1598407..1598892 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag N4555_RS07945 Protein ID WP_000801912.1
Coordinates 1598138..1598416 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS07940 (1595366) 1595366..1598071 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
N4555_RS07945 (1598138) 1598138..1598416 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
N4555_RS07950 (1598407) 1598407..1598892 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
N4555_RS07955 (1598942) 1598942..1599970 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
N4555_RS07960 (1599974) 1599974..1601200 - 1227 WP_001105473.1 RNA-splicing ligase RtcB -
N4555_RS07965 (1601388) 1601388..1602986 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
N4555_RS07970 (1602968) 1602968..1603726 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T258714 WP_001301452.1 NZ_CP104639:1598407-1598892 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT258714 WP_000801912.1 NZ_CP104639:1598138-1598416 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References