Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 750514..751544 | Replicon | chromosome |
| Accession | NC_016801 | ||
| Organism | Corynebacterium diphtheriae C7 (beta) | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | CDC7B_RS03705 | Protein ID | WP_014303124.1 |
| Coordinates | 750514..750966 (-) | Length | 151 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A806GUF5 |
| Locus tag | CDC7B_RS03710 | Protein ID | WP_014318824.1 |
| Coordinates | 750978..751544 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CDC7B_RS03690 | 747171..748025 | + | 855 | WP_014303121.1 | hypothetical protein | - |
| CDC7B_RS03695 | 748018..748926 | - | 909 | WP_014309246.1 | DUF1906 domain-containing protein | - |
| CDC7B_RS03700 | 749055..750254 | - | 1200 | WP_014318823.1 | cation:proton antiporter | - |
| CDC7B_RS03705 | 750514..750966 | - | 453 | WP_014303124.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| CDC7B_RS03710 | 750978..751544 | - | 567 | WP_014318824.1 | SocA family protein | Antitoxin |
| CDC7B_RS13235 | 751877..752152 | + | 276 | WP_014309249.1 | hypothetical protein | - |
| CDC7B_RS03730 | 752824..753099 | + | 276 | WP_014301596.1 | hypothetical protein | - |
| CDC7B_RS03735 | 753106..753858 | + | 753 | WP_014318826.1 | precorrin-6A synthase (deacetylating) | - |
| CDC7B_RS03740 | 753877..754134 | - | 258 | WP_010934589.1 | mycoredoxin | - |
| CDC7B_RS03745 | 754155..754658 | - | 504 | WP_014303129.1 | dihydrofolate reductase | - |
| CDC7B_RS03750 | 754658..755470 | - | 813 | WP_014318827.1 | thymidylate synthase | - |
| CDC7B_RS03755 | 755564..756322 | - | 759 | WP_014318828.1 | 3'(2'),5'-bisphosphate nucleotidase CysQ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 750514..761175 | 10661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 151 a.a. Molecular weight: 16477.60 Da Isoelectric Point: 7.7987
>T25871 WP_014303124.1 NC_016801:c750966-750514 [Corynebacterium diphtheriae C7 (beta)]
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 453 bp
>T25871 NC_016801:c750966-750514 [Corynebacterium diphtheriae C7 (beta)]
GTGTCGGGAAATAGCGGGGCGTCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA
GTGTCGGGAAATAGCGGGGCGTCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 189 a.a. Molecular weight: 21053.55 Da Isoelectric Point: 4.5592
>AT25871 WP_014318824.1 NC_016801:c751544-750978 [Corynebacterium diphtheriae C7 (beta)]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
>AT25871 NC_016801:c751544-750978 [Corynebacterium diphtheriae C7 (beta)]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|