Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4637371..4638185 Replicon chromosome
Accession NZ_CP104638
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N4311_RS23600 Protein ID WP_000971655.1
Coordinates 4637371..4637898 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N4311_RS23605 Protein ID WP_000855694.1
Coordinates 4637895..4638185 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS23570 (4633653) 4633653..4634051 + 399 Protein_4415 cytoplasmic protein -
N4311_RS23575 (4634242) 4634242..4634481 + 240 Protein_4416 hypothetical protein -
N4311_RS23580 (4634638) 4634638..4635306 + 669 WP_000445914.1 hypothetical protein -
N4311_RS23585 (4635333) 4635333..4635827 + 495 WP_000424948.1 hypothetical protein -
N4311_RS23590 (4635999) 4635999..4636655 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N4311_RS23595 (4636888) 4636888..4637298 + 411 Protein_4420 transposase -
N4311_RS23600 (4637371) 4637371..4637898 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N4311_RS23605 (4637895) 4637895..4638185 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N4311_RS23610 (4638455) 4638455..4638633 - 179 Protein_4423 IS3 family transposase -
N4311_RS23615 (4638874) 4638874..4639200 + 327 WP_000393302.1 hypothetical protein -
N4311_RS23620 (4639473) 4639473..4639820 - 348 WP_001669174.1 DUF1493 family protein -
N4311_RS23625 (4639805) 4639805..4640254 - 450 WP_000381610.1 membrane protein -
N4311_RS23630 (4640686) 4640686..4641129 - 444 WP_000715099.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4311_RS23635 (4641585) 4641585..4642235 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4637074..4637298 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T258709 WP_000971655.1 NZ_CP104638:c4637898-4637371 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258709 WP_000855694.1 NZ_CP104638:c4638185-4637895 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References