Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4482706..4483331 Replicon chromosome
Accession NZ_CP104638
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4311_RS22915 Protein ID WP_000911337.1
Coordinates 4482933..4483331 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag N4311_RS22910 Protein ID WP_000557545.1
Coordinates 4482706..4482933 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS22880 (4477751) 4477751..4479268 + 1518 WP_000003339.1 lysine--tRNA ligase -
N4311_RS22885 (4479344) 4479344..4479889 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
N4311_RS22890 (4480154) 4480154..4480912 + 759 WP_000244328.1 amidase activator ActS -
N4311_RS22900 (4481197) 4481197..4482003 - 807 WP_010989071.1 DUF1460 domain-containing protein -
N4311_RS22905 (4482278) 4482278..4482529 - 252 WP_001540858.1 hypothetical protein -
N4311_RS22910 (4482706) 4482706..4482933 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4311_RS22915 (4482933) 4482933..4483331 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
N4311_RS22920 (4484139) 4484139..4484675 + 537 WP_001038502.1 STM3031 family outer membrane protein -
N4311_RS22925 (4484722) 4484722..4485354 + 633 WP_000835265.1 YfdX family protein -
N4311_RS22930 (4486073) 4486073..4486654 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4482278..4491114 8836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T258708 WP_000911337.1 NZ_CP104638:4482933-4483331 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT258708 WP_000557545.1 NZ_CP104638:4482706-4482933 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References