Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3108206..3108987 Replicon chromosome
Accession NZ_CP104638
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag N4311_RS16320 Protein ID WP_000625912.1
Coordinates 3108206..3108697 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag N4311_RS16325 Protein ID WP_001110450.1
Coordinates 3108694..3108987 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS16290 (3104467) 3104467..3104964 - 498 WP_001670425.1 FimD/PapC N-terminal domain-containing protein -
N4311_RS16295 (3105088) 3105088..3105918 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
N4311_RS16300 (3106120) 3106120..3106425 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
N4311_RS16305 (3106956) 3106956..3107099 + 144 Protein_3009 transposase -
N4311_RS16310 (3107116) 3107116..3107462 + 347 Protein_3010 Rpn family recombination-promoting nuclease/putative transposase -
N4311_RS16315 (3107743) 3107743..3107991 - 249 Protein_3011 IS481 family transposase -
N4311_RS16320 (3108206) 3108206..3108697 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
N4311_RS16325 (3108694) 3108694..3108987 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
N4311_RS16330 (3109304) 3109304..3109526 + 223 Protein_3014 hypothetical protein -
N4311_RS16335 (3109790) 3109790..3110665 + 876 WP_000921676.1 AraC family transcriptional regulator -
N4311_RS16340 (3110662) 3110662..3110949 + 288 WP_001269916.1 transcriptional regulator RtsB -
N4311_RS16345 (3110942) 3110942..3111124 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
N4311_RS16350 (3111144) 3111144..3111243 + 100 Protein_3018 hypothetical protein -
N4311_RS16355 (3111356) 3111356..3111490 + 135 Protein_3019 hypothetical protein -
N4311_RS16360 (3111785) 3111785..3112690 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3101296..3110949 9653
- inside Genomic island - - 3101296..3111124 9828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T258703 WP_000625912.1 NZ_CP104638:c3108697-3108206 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT258703 WP_001110450.1 NZ_CP104638:c3108987-3108694 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References