Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2991031..2991547 Replicon chromosome
Accession NZ_CP104638
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name relE Uniprot ID A0A0R9NWE9
Locus tag N4311_RS15670 Protein ID WP_000220579.1
Coordinates 2991031..2991315 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4311_RS15675 Protein ID WP_000212724.1
Coordinates 2991305..2991547 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS15655 (2986147) 2986147..2987799 + 1653 WP_000155055.1 alpha,alpha-phosphotrehalase -
N4311_RS15660 (2988208) 2988208..2990346 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
N4311_RS15665 (2990563) 2990563..2991027 + 465 WP_001009175.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4311_RS15670 (2991031) 2991031..2991315 - 285 WP_000220579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4311_RS15675 (2991305) 2991305..2991547 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4311_RS15680 (2991625) 2991625..2993538 - 1914 WP_001212131.1 BglG family transcription antiterminator -
N4311_RS15685 (2993555) 2993555..2994295 - 741 WP_000779247.1 KDGP aldolase family protein -
N4311_RS15690 (2994292) 2994292..2995410 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4311_RS15695 (2995394) 2995394..2996527 - 1134 WP_000459949.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10884.70 Da        Isoelectric Point: 10.0482

>T258702 WP_000220579.1 NZ_CP104638:c2991315-2991031 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDTNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258702 WP_000212724.1 NZ_CP104638:c2991547-2991305 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NWE9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References