Detailed information of TA system TA025870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 101208..101691
• Replicon: chromosome
• Accession: NC_016801
• Organism: Corynebacterium diphtheriae C7 (beta)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A806GHY4
• Locus tag: CDC7B_RS00535
• Protein ID: WP_014302726.1
• Coordinates: 101428..101691 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CDC7B_RS00530
• Protein ID: WP_003850117.1
• Coordinates: 101208..101444 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDC7B_RS00500	96587..97142	+	556	Protein_95	LysE family transporter	-
CDC7B_RS00505	97251..98009	+	759	WP_003850109.1	hypothetical protein	-
CDC7B_RS12725	98289..99811	+	1523	Protein_97	IS30 family transposase	-
CDC7B_RS00520	100022..100705	-	684	WP_014302723.1	hypothetical protein	-
CDC7B_RS00530	101208..101444	+	237	WP_003850117.1	ribbon-helix-helix domain-containing protein	Antitoxin
CDC7B_RS00535	101428..101691	+	264	WP_014302726.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDC7B_RS00540	101818..102111	+	294	WP_014302727.1	RNA-binding S4 domain-containing protein	-
CDC7B_RS00545	102111..102935	+	825	WP_014301205.1	VOC family protein	-
CDC7B_RS00550	102941..103246	+	306	WP_003850125.1	MGMT family protein	-
CDC7B_RS00555	103256..104176	-	921	WP_003850127.1	alpha/beta hydrolase	-
CDC7B_RS00560	104316..104942	+	627	WP_014318472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	67222..102111	34889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (7-43)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9911.45 Da
• Isoelectric Point: 10.9201

>T25870 WP_014302726.1 NC_016801:101428-101691 [Corynebacterium diphtheriae C7 (beta)]
VAWEISFSPRAVKSFKKLDTGEQRRVSKFLREVGALEDPRLRGKALTANKSGLWRWRVGDYRIIADIVDARVVVVVVDVG
HRSKAYD

Nucleotide

• Length: 264 bp

>T25870 NC_016801:101428-101691 [Corynebacterium diphtheriae C7 (beta)]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGCCTACGACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8911.02 Da
• Isoelectric Point: 4.8604

>AT25870 WP_003850117.1 NC_016801:101208-101444 [Corynebacterium diphtheriae C7 (beta)]
MSGSVISLRIDDEQKRRLDELSRRTGRPCSFYLREALSAHLADLEYVYRLEEEAAQVRRGELGTVPLSQLERECGLGD

Nucleotide

• Length: 237 bp

>AT25870 NC_016801:101208-101444 [Corynebacterium diphtheriae C7 (beta)]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGCGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Structures

Toxin

• AlphaFold DB: A0A806GHY4