Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2301237..2301857 Replicon chromosome
Accession NZ_CP104638
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4311_RS12495 Protein ID WP_001280991.1
Coordinates 2301639..2301857 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4311_RS12490 Protein ID WP_000344807.1
Coordinates 2301237..2301611 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS12480 (2296376) 2296376..2297569 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4311_RS12485 (2297592) 2297592..2300741 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4311_RS12490 (2301237) 2301237..2301611 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4311_RS12495 (2301639) 2301639..2301857 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4311_RS12500 (2302036) 2302036..2302587 + 552 WP_001278792.1 maltose O-acetyltransferase -
N4311_RS12505 (2302704) 2302704..2303174 + 471 WP_000136181.1 YlaC family protein -
N4311_RS12510 (2303230) 2303230..2303370 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4311_RS12515 (2303376) 2303376..2303636 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4311_RS12520 (2303861) 2303861..2305411 + 1551 WP_000213138.1 EAL domain-containing protein -
N4311_RS12530 (2305642) 2305642..2306031 + 390 WP_000961287.1 MGMT family protein -
N4311_RS12535 (2306064) 2306064..2306633 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258699 WP_001280991.1 NZ_CP104638:2301639-2301857 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258699 WP_000344807.1 NZ_CP104638:2301237-2301611 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References