258693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 10281..10746 Replicon plasmid pHNAH212872-3
Accession NZ_CP104633
Organism Escherichia coli strain AHM21C2872I

Toxin (Protein)


Gene name TsxA Uniprot ID A0A5Y6UAV0
Locus tag N5855_RS26250 Protein ID WP_001230708.1
Coordinates 10495..10746 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag N5855_RS26245 Protein ID WP_000801440.1
Coordinates 10281..10508 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5855_RS26205 (N5855_26155) 5651..5827 - 177 WP_000660496.1 hypothetical protein -
N5855_RS26210 (N5855_26160) 6004..6219 - 216 WP_000760375.1 EexN family lipoprotein -
N5855_RS26215 (N5855_26165) 6216..6509 - 294 WP_000134733.1 sigma factor-like helix-turn-helix DNA-binding protein -
N5855_RS26220 (N5855_26170) 6586..7815 - 1230 WP_058815700.1 DNA relaxase/nickase TaxC -
N5855_RS26225 (N5855_26175) 7819..8322 - 504 WP_000781818.1 DNA distortion polypeptide 1 -
N5855_RS26230 (N5855_26180) 8685..8858 - 174 WP_071821486.1 type II toxin-antitoxin system HicB family antitoxin -
N5855_RS26235 (N5855_26185) 9133..9498 - 366 WP_000854262.1 hypothetical protein -
N5855_RS26240 (N5855_26190) 9590..9889 - 300 WP_000650313.1 hypothetical protein -
N5855_RS26245 (N5855_26195) 10281..10508 - 228 WP_000801440.1 hypothetical protein Antitoxin
N5855_RS26250 (N5855_26200) 10495..10746 - 252 WP_001230708.1 hypothetical protein Toxin
N5855_RS26255 (N5855_26205) 10743..11285 - 543 WP_001083908.1 hypothetical protein -
N5855_RS26260 (N5855_26210) 11390..11905 - 516 WP_001025396.1 J domain-containing protein -
N5855_RS26265 (N5855_26215) 12544..12894 - 351 WP_000127483.1 hypothetical protein -
N5855_RS26270 (N5855_26220) 12891..13226 - 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33795 33795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9750.19 Da        Isoelectric Point: 9.8104

>T258693 WP_001230708.1 NZ_CP104633:c10746-10495 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLRKDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT258693 WP_000801440.1 NZ_CP104633:c10508-10281 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y6UAV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References