Detailed information of TA system TA025869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2304785..2305268
• Replicon: chromosome
• Accession: NC_016800
• Organism: Corynebacterium diphtheriae BH8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CDBH8_RS10990
• Protein ID: WP_014317255.1
• Coordinates: 2304785..2305054 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CDBH8_RS12675
• Protein ID: WP_014317256.1
• Coordinates: 2305035..2305268 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDBH8_RS10970	2301527..2302126	-	600	Protein_2137	RloB domain-containing protein	-
CDBH8_RS10975	2302153..2303484	-	1332	WP_014317252.1	ATP-binding protein	-
CDBH8_RS10980	2303579..2304022	-	444	WP_014318335.1	type I restriction endonuclease subunit S	-
CDBH8_RS10990	2304785..2305054	-	270	WP_014317255.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDBH8_RS12675	2305035..2305268	-	234	WP_014317256.1	ribbon-helix-helix protein, CopG family	Antitoxin
CDBH8_RS13095	2305581..2306575	+	995	Protein_2142	IS3 family transposase	-
CDBH8_RS11020	2307039..2307472	+	434	Protein_2143	hypothetical protein	-
CDBH8_RS11025	2307420..2307671	+	252	WP_042382028.1	hypothetical protein	-
CDBH8_RS11035	2307903..2308313	+	411	WP_014317263.1	helix-turn-helix transcriptional regulator	-
CDBH8_RS13470	2308763..2308912	+	150	WP_014317264.1	hypothetical protein	-
CDBH8_RS11040	2309486..2309857	+	372	WP_004567374.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10217.79 Da
• Isoelectric Point: 10.6133

>T25869 WP_014317255.1 NC_016800:c2305054-2304785 [Corynebacterium diphtheriae BH8]
VTSWAIEFSPRAAKELRKLGRPVQKHIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVVVVVSI
GHRSQVYED

Nucleotide

• Length: 270 bp

>T25869 NC_016800:c2305054-2304785 [Corynebacterium diphtheriae BH8]
GTGACCTCTTGGGCGATTGAGTTTTCTCCGCGTGCTGCTAAAGAGCTCCGGAAGCTTGGCCGGCCAGTTCAAAAGCACAT
TGTTGCGTATCTTCGAGAAATTTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGGTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCGTTGCAGCTATTGAAGATGATCGTGTTGTCGTCGTCGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8917.92 Da
• Isoelectric Point: 4.4766

>AT25869 WP_014317256.1 NC_016800:c2305268-2305035 [Corynebacterium diphtheriae BH8]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETISLDEVERDLLGD

Nucleotide

• Length: 234 bp

>AT25869 NC_016800:c2305268-2305035 [Corynebacterium diphtheriae BH8]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGATCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAGCTTGGACGAGGTAGAGCGTGACCTCTTGGGCGATTGA