Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4666428..4666978 Replicon chromosome
Accession NZ_CP104629
Organism Escherichia coli strain AHM21C2872I

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag N5855_RS22325 Protein ID WP_001160975.1
Coordinates 4666664..4666978 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D3H431
Locus tag N5855_RS22320 Protein ID WP_000125565.1
Coordinates 4666428..4666661 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5855_RS22295 (4661499) 4661499..4661786 + 288 WP_000203741.1 ferredoxin-like protein FixX -
N5855_RS22300 (4661844) 4661844..4663175 + 1332 WP_001183198.1 MFS transporter -
N5855_RS22305 (4663286) 4663286..4663816 + 531 WP_000600718.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
N5855_RS22310 (4663809) 4663809..4665671 + 1863 WP_040234481.1 glutathione-regulated potassium-efflux system protein KefC -
N5855_RS22315 (4665863) 4665863..4666342 + 480 WP_001487721.1 type 3 dihydrofolate reductase -
N5855_RS22320 (4666428) 4666428..4666661 + 234 WP_000125565.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N5855_RS22325 (4666664) 4666664..4666978 + 315 WP_001160975.1 CcdB family protein Toxin
N5855_RS22330 (4666975) 4666975..4667823 - 849 WP_021556397.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
N5855_RS22335 (4667830) 4667830..4668207 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
N5855_RS22340 (4668210) 4668210..4669031 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
N5855_RS22345 (4669028) 4669028..4670017 - 990 WP_021556398.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
N5855_RS22350 (4670017) 4670017..4671303 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T258687 WP_001160975.1 NZ_CP104629:4666664-4666978 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8599.64 Da        Isoelectric Point: 6.9791

>AT258687 WP_000125565.1 NZ_CP104629:4666428-4666661 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRRF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A090NGC7

References