Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4454735..4455330 Replicon chromosome
Accession NZ_CP104629
Organism Escherichia coli strain AHM21C2872I

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N5855_RS21360 Protein ID WP_000239579.1
Coordinates 4454980..4455330 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N5855_RS21355 Protein ID WP_001223208.1
Coordinates 4454735..4454986 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5855_RS21345 (4450399) 4450399..4454178 + 3780 WP_021557470.1 autotransporter assembly complex protein TamB -
N5855_RS21350 (4454181) 4454181..4454522 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N5855_RS21355 (4454735) 4454735..4454986 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N5855_RS21360 (4454980) 4454980..4455330 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N5855_RS21365 (4455410) 4455410..4455940 - 531 WP_000055072.1 inorganic diphosphatase -
N5855_RS21370 (4456250) 4456250..4457206 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N5855_RS21375 (4457346) 4457346..4458848 + 1503 WP_021557471.1 sugar ABC transporter ATP-binding protein -
N5855_RS21380 (4458862) 4458862..4459884 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T258686 WP_000239579.1 NZ_CP104629:4454980-4455330 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT258686 WP_001223208.1 NZ_CP104629:4454735-4454986 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References