Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3538179..3538810 Replicon chromosome
Accession NZ_CP104629
Organism Escherichia coli strain AHM21C2872I

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M1UJK7
Locus tag N5855_RS17095 Protein ID WP_001259382.1
Coordinates 3538535..3538810 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N5855_RS17090 Protein ID WP_000593555.1
Coordinates 3538179..3538538 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5855_RS17060 (3533291) 3533291..3533764 + 474 WP_001161650.1 PTS sugar transporter subunit IIA -
N5855_RS17065 (3533761) 3533761..3534042 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
N5855_RS17070 (3534119) 3534119..3535477 + 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
N5855_RS17075 (3535470) 3535470..3536978 + 1509 WP_021557288.1 FGGY-family carbohydrate kinase -
N5855_RS17080 (3536968) 3536968..3537237 + 270 WP_000933060.1 HPr family phosphocarrier protein -
N5855_RS17085 (3537269) 3537269..3538129 + 861 WP_021557289.1 class II aldolase -
N5855_RS17090 (3538179) 3538179..3538538 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5855_RS17095 (3538535) 3538535..3538810 - 276 WP_001259382.1 type II toxin-antitoxin system HicA family toxin Toxin
N5855_RS17100 (3538883) 3538883..3540007 - 1125 WP_021557290.1 ABC transporter permease -
N5855_RS17105 (3540007) 3540007..3542742 - 2736 WP_000149130.1 ribosome-associated ATPase/putative transporter RbbA -
N5855_RS17110 (3542739) 3542739..3543806 - 1068 WP_000361517.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3532520..3547666 15146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.91 Da        Isoelectric Point: 10.7076

>T258683 WP_001259382.1 NZ_CP104629:c3538810-3538535 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258683 WP_000593555.1 NZ_CP104629:c3538538-3538179 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1UJK7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References