Detailed information of TA system TA025868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2365670..2366153
• Replicon: chromosome
• Accession: NC_016799
• Organism: Corynebacterium diphtheriae 31A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CD31A_RS11175
• Protein ID: WP_014317255.1
• Coordinates: 2365670..2365939 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CD31A_RS12795
• Protein ID: WP_014317256.1
• Coordinates: 2365920..2366153 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD31A_RS11150	2362412..2363011	-	600	Protein_2194	RloB domain-containing protein	-
CD31A_RS11155	2363038..2364369	-	1332	WP_014317252.1	ATP-binding protein	-
CD31A_RS11175	2365670..2365939	-	270	WP_014317255.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CD31A_RS12795	2365920..2366153	-	234	WP_014317256.1	ribbon-helix-helix protein, CopG family	Antitoxin
CD31A_RS13165	2366466..2367460	+	995	Protein_2198	IS3 family transposase	-
CD31A_RS11205	2367924..2368357	+	434	Protein_2199	hypothetical protein	-
CD31A_RS11210	2368305..2368556	+	252	WP_042382028.1	hypothetical protein	-
CD31A_RS11220	2368788..2369198	+	411	WP_014317263.1	helix-turn-helix transcriptional regulator	-
CD31A_RS13530	2369648..2369797	+	150	WP_014317264.1	hypothetical protein	-
CD31A_RS11225	2370371..2370742	+	372	WP_004567374.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2346580..2385976	39396

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10217.79 Da
• Isoelectric Point: 10.6133

>T25868 WP_014317255.1 NC_016799:c2365939-2365670 [Corynebacterium diphtheriae 31A]
VTSWAIEFSPRAAKELRKLGRPVQKHIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVVVVVSI
GHRSQVYED

Nucleotide

• Length: 270 bp

>T25868 NC_016799:c2365939-2365670 [Corynebacterium diphtheriae 31A]
GTGACCTCTTGGGCGATTGAGTTTTCTCCGCGTGCTGCTAAAGAGCTCCGGAAGCTTGGCCGGCCAGTTCAAAAGCACAT
TGTTGCGTATCTTCGAGAAATTTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGGTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCGTTGCAGCTATTGAAGATGATCGTGTTGTCGTCGTCGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8917.92 Da
• Isoelectric Point: 4.4766

>AT25868 WP_014317256.1 NC_016799:c2366153-2365920 [Corynebacterium diphtheriae 31A]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETISLDEVERDLLGD

Nucleotide

• Length: 234 bp

>AT25868 NC_016799:c2366153-2365920 [Corynebacterium diphtheriae 31A]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGATCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAGCTTGGACGAGGTAGAGCGTGACCTCTTGGGCGATTGA