Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5128117..5128742 Replicon chromosome
Accession NZ_CP104627
Organism Klebsiella pneumoniae strain AHM21C2836KI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5857_RS24825 Protein ID WP_047718441.1
Coordinates 5128117..5128500 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag N5857_RS24830 Protein ID WP_004150355.1
Coordinates 5128500..5128742 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5857_RS24810 (5125483) 5125483..5126385 + 903 WP_109963920.1 formate dehydrogenase subunit beta -
N5857_RS24815 (5126382) 5126382..5127017 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N5857_RS24820 (5127014) 5127014..5127943 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N5857_RS24825 (5128117) 5128117..5128500 - 384 WP_047718441.1 type II toxin-antitoxin system VapC family toxin Toxin
N5857_RS24830 (5128500) 5128500..5128742 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
N5857_RS24835 (5128947) 5128947..5129864 + 918 WP_200541565.1 alpha/beta hydrolase -
N5857_RS24840 (5129878) 5129878..5130819 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N5857_RS24845 (5130864) 5130864..5131301 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N5857_RS24850 (5131298) 5131298..5132158 - 861 WP_004146232.1 virulence factor BrkB family protein -
N5857_RS24855 (5132152) 5132152..5132751 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14350.59 Da        Isoelectric Point: 7.3178

>T258669 WP_047718441.1 NZ_CP104627:c5128500-5128117 [Klebsiella pneumoniae]
MTSGSALFDTSILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT258669 WP_004150355.1 NZ_CP104627:c5128742-5128500 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References