Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4804120..4805801 | Replicon | chromosome |
| Accession | NZ_CP104627 | ||
| Organism | Klebsiella pneumoniae strain AHM21C2836KI | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | N5857_RS23320 | Protein ID | WP_200541531.1 |
| Coordinates | 4804120..4805037 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A2L1C4M5 |
| Locus tag | N5857_RS23325 | Protein ID | WP_004192584.1 |
| Coordinates | 4805043..4805801 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5857_RS23300 (4799426) | 4799426..4800946 | + | 1521 | WP_048291089.1 | sugar ABC transporter ATP-binding protein | - |
| N5857_RS23305 (4800943) | 4800943..4801941 | + | 999 | WP_004186549.1 | ribose ABC transporter permease | - |
| N5857_RS23310 (4801972) | 4801972..4802913 | + | 942 | WP_200541532.1 | ABC transporter substrate-binding protein | - |
| N5857_RS23315 (4802988) | 4802988..4803995 | + | 1008 | WP_004210019.1 | carbohydrate kinase family protein | - |
| N5857_RS23320 (4804120) | 4804120..4805037 | - | 918 | WP_200541531.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| N5857_RS23325 (4805043) | 4805043..4805801 | - | 759 | WP_004192584.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| N5857_RS23330 (4805887) | 4805887..4806615 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| N5857_RS23335 (4806888) | 4806888..4809035 | + | 2148 | WP_077598921.1 | formate dehydrogenase subunit alpha | - |
| N5857_RS23340 (4809265) | 4809265..4809951 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34686.17 Da Isoelectric Point: 5.7799
>T258668 WP_200541531.1 NZ_CP104627:c4805037-4804120 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQNLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQNLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28582.94 Da Isoelectric Point: 10.0870
>AT258668 WP_004192584.1 NZ_CP104627:c4805801-4805043 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|