Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4647602..4648118 Replicon chromosome
Accession NZ_CP104627
Organism Klebsiella pneumoniae strain AHM21C2836KI

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag N5857_RS22525 Protein ID WP_002886902.1
Coordinates 4647602..4647886 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N5857_RS22530 Protein ID WP_002886901.1
Coordinates 4647876..4648118 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5857_RS22500 (4642998) 4642998..4643261 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
N5857_RS22505 (4643391) 4643391..4643564 + 174 WP_232552808.1 hypothetical protein -
N5857_RS22510 (4643567) 4643567..4644310 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N5857_RS22515 (4644667) 4644667..4646805 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N5857_RS22520 (4647134) 4647134..4647598 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5857_RS22525 (4647602) 4647602..4647886 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5857_RS22530 (4647876) 4647876..4648118 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5857_RS22535 (4648196) 4648196..4650106 - 1911 WP_004152270.1 PRD domain-containing protein -
N5857_RS22540 (4650129) 4650129..4651283 - 1155 WP_004178372.1 lactonase family protein -
N5857_RS22545 (4651350) 4651350..4652090 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T258667 WP_002886902.1 NZ_CP104627:c4647886-4647602 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT258667 WP_002886901.1 NZ_CP104627:c4648118-4647876 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References