Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2615662..2617250 Replicon chromosome
Accession NZ_CP104627
Organism Klebsiella pneumoniae strain AHM21C2836KI

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag N5857_RS12820 Protein ID WP_002904792.1
Coordinates 2615662..2616984 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N5857_RS12825 Protein ID WP_002904790.1
Coordinates 2616984..2617250 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5857_RS12805 (2610718) 2610718..2613219 + 2502 WP_023158393.1 fimbria/pilus outer membrane usher protein -
N5857_RS12810 (2613207) 2613207..2614211 + 1005 WP_004184029.1 fimbrial protein -
N5857_RS12815 (2614353) 2614353..2615645 + 1293 WP_200541255.1 glycoside hydrolase family 10 protein -
N5857_RS12820 (2615662) 2615662..2616984 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
N5857_RS12825 (2616984) 2616984..2617250 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5857_RS12830 (2617516) 2617516..2617842 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N5857_RS12835 (2617839) 2617839..2618339 - 501 WP_004176202.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N5857_RS12840 (2618317) 2618317..2619696 - 1380 WP_032412205.1 nucleobase:cation symporter-2 family protein -
N5857_RS12845 (2620042) 2620042..2621196 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N5857_RS12850 (2621177) 2621177..2622100 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T258663 WP_002904792.1 NZ_CP104627:c2616984-2615662 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT258663 WP_002904790.1 NZ_CP104627:c2617250-2616984 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References