Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 787428..788085 Replicon chromosome
Accession NZ_CP104627
Organism Klebsiella pneumoniae strain AHM21C2836KI

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N5857_RS03935 Protein ID WP_002916310.1
Coordinates 787675..788085 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N5857_RS03930 Protein ID WP_002916312.1
Coordinates 787428..787694 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5857_RS03905 (782636) 782636..784069 - 1434 WP_040242642.1 6-phospho-beta-glucosidase -
N5857_RS03910 (784188) 784188..784916 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N5857_RS03915 (784966) 784966..785277 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N5857_RS03920 (785441) 785441..786100 + 660 WP_002916317.1 hemolysin III family protein -
N5857_RS03925 (786199) 786199..787182 - 984 WP_040242645.1 tRNA-modifying protein YgfZ -
N5857_RS03930 (787428) 787428..787694 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N5857_RS03935 (787675) 787675..788085 + 411 WP_002916310.1 protein YgfX Toxin
N5857_RS03940 (788092) 788092..788613 - 522 WP_040242647.1 flavodoxin FldB -
N5857_RS03945 (788714) 788714..789610 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N5857_RS03950 (789633) 789633..790346 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5857_RS03955 (790352) 790352..792085 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T258658 WP_002916310.1 NZ_CP104627:787675-788085 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT258658 WP_002916312.1 NZ_CP104627:787428-787694 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References