Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2521..3043 Replicon plasmid pHNAH968-4
Accession NZ_CP104623
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N5859_RS24865 Protein ID WP_000220561.1
Coordinates 2762..3043 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N5859_RS24860 Protein ID WP_000121743.1
Coordinates 2521..2772 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS24855 (447) 447..1286 - 840 WP_001352874.1 replication initiation protein -
N5859_RS24860 (2521) 2521..2772 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N5859_RS24865 (2762) 2762..3043 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5859_RS24870 (3393) 3393..3908 + 516 WP_001025387.1 J domain-containing protein -
N5859_RS24875 (3982) 3982..4530 + 549 WP_001178641.1 hypothetical protein -
N5859_RS24880 (4539) 4539..4808 + 270 WP_001006718.1 hypothetical protein -
N5859_RS24885 (4798) 4798..5040 + 243 WP_000008708.1 hypothetical protein -
N5859_RS24890 (5173) 5173..5877 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
N5859_RS24895 (5883) 5883..6023 + 141 WP_001044210.1 hypothetical protein -
N5859_RS24900 (6509) 6509..7246 + 738 WP_001446887.1 recombinase family protein -
N5859_RS24905 (7243) 7243..7467 + 225 WP_000743213.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR - 1..30784 30784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T258655 WP_000220561.1 NZ_CP104623:2762-3043 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT258655 WP_000121743.1 NZ_CP104623:2521-2772 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References