258653

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 12338..12839 Replicon plasmid pHNAH968-3
Accession NZ_CP104622
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name TsxA Uniprot ID H1ZXU8
Locus tag N5859_RS24525 Protein ID WP_000702247.1
Coordinates 12338..12598 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag N5859_RS24530 Protein ID WP_001132407.1
Coordinates 12588..12839 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS24495 (N5859_24410) 8460..9722 - 1263 WP_000608644.1 IS1380-like element ISEcp1 family transposase -
N5859_RS24500 (N5859_24415) 10480..10809 + 330 WP_000855120.1 hypothetical protein -
N5859_RS24505 (N5859_24420) 10918..11064 - 147 WP_001356709.1 hypothetical protein -
N5859_RS24510 (N5859_24425) 11391..11714 + 324 WP_000427403.1 hypothetical protein -
N5859_RS24515 (N5859_24430) 11756..11965 + 210 WP_000866036.1 hypothetical protein -
N5859_RS24520 (N5859_24435) 12062..12286 + 225 WP_000814381.1 hypothetical protein -
N5859_RS24525 (N5859_24440) 12338..12598 + 261 WP_000702247.1 hypothetical protein Toxin
N5859_RS24530 (N5859_24445) 12588..12839 + 252 WP_001132407.1 transcriptional regulator Antitoxin
N5859_RS24535 (N5859_24450) 13389..13667 + 279 WP_000545938.1 hypothetical protein -
N5859_RS24540 (N5859_24455) 14087..14353 + 267 WP_000681608.1 type II toxin-antitoxin system HicB family antitoxin -
N5859_RS24545 (N5859_24460) 14460..14903 - 444 WP_000068545.1 hypothetical protein -
N5859_RS24550 (N5859_24465) 15200..15382 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
N5859_RS24555 (N5859_24470) 15407..15844 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
N5859_RS24560 (N5859_24475) 15975..16301 - 327 WP_063078684.1 hypothetical protein -
N5859_RS24565 (N5859_24480) 16321..17028 - 708 WP_021503228.1 hypothetical protein -
N5859_RS24570 (N5859_24485) 17030..17782 - 753 WP_063078685.1 conjugal transfer protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-55 / mcr-1.1 - 1..66033 66033
- flank IS/Tn blaCTX-M-55 - 7332..9722 2390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9817.29 Da        Isoelectric Point: 10.0665

>T258653 WP_000702247.1 NZ_CP104622:12338-12598 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.77 Da        Isoelectric Point: 9.8120

>AT258653 WP_001132407.1 NZ_CP104622:12588-12839 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1P8DNC0

Antitoxin

Source ID Structure

References