Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 2343035..2343518 Replicon chromosome
Accession NC_016789
Organism Corynebacterium diphtheriae PW8

Toxin (Protein)


Gene name relE Uniprot ID A0A6J4WN23
Locus tag CDPW8_RS10955 Protein ID WP_014307502.1
Coordinates 2343035..2343304 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A6J4WZ27
Locus tag CDPW8_RS10960 Protein ID WP_014307503.1
Coordinates 2343285..2343518 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDPW8_RS13195 2338433..2338573 - 141 WP_014311009.1 hypothetical protein -
CDPW8_RS10935 2338994..2339302 + 309 WP_050816589.1 type II toxin-antitoxin system RelE/ParE family toxin -
CDPW8_RS10940 2339317..2340411 + 1095 WP_014311011.1 HigA family addiction module antidote protein -
CDPW8_RS10945 2340468..2340695 - 228 WP_014311012.1 iron chelate uptake ABC transporter family permease subunit -
CDPW8_RS10950 2340835..2342646 + 1812 WP_014311013.1 N-acetylmuramoyl-L-alanine amidase -
CDPW8_RS10955 2343035..2343304 - 270 WP_014307502.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDPW8_RS10960 2343285..2343518 - 234 WP_014307503.1 ribbon-helix-helix protein, CopG family Antitoxin
CDPW8_RS10970 2344256..2344855 - 600 WP_041627054.1 RloB family protein -
CDPW8_RS10975 2344883..2346214 - 1332 WP_014307506.1 ATP-binding protein -
CDPW8_RS10980 2346309..2346887 - 579 WP_014311015.1 restriction endonuclease subunit S -
CDPW8_RS10985 2347270..2347530 - 261 WP_014304055.1 hypothetical protein -
CDPW8_RS10990 2347637..2348434 - 798 WP_014304056.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2339317..2368132 28815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10338.92 Da        Isoelectric Point: 10.6099

>T25865 WP_014307502.1 NC_016789:c2343304-2343035 [Corynebacterium diphtheriae PW8]
VTSWTIEFSPRAAKELRKLDRPVQKRIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVIVVVSI
GHRSQVYED

Download         Length: 270 bp

>T25865 NC_016789:c2343304-2343035 [Corynebacterium diphtheriae PW8]
GTGACCTCTTGGACGATTGAGTTTTCTCCGCGTGCTGCTAAAGAGCTCCGGAAGCTTGACCGGCCAGTTCAAAAGCGCAT
TGTTGCGTATCTTCGAGAAATCTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGGTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCGTTGCAGCTATTGAAGATGATCGTGTTGTCATCGTTGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9002.99 Da        Isoelectric Point: 4.3904

>AT25865 WP_014307503.1 NC_016789:c2343518-2343285 [Corynebacterium diphtheriae PW8]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETINLDEVERDLLDD

Download         Length: 234 bp

>AT25865 NC_016789:c2343518-2343285 [Corynebacterium diphtheriae PW8]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGGTCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAACTTGGACGAGGTAGAGCGTGACCTCTTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6J4WN23

Antitoxin

Source ID Structure
AlphaFold DB A0A6J4WZ27

References