Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1824..2359 Replicon plasmid pHNAH968-1
Accession NZ_CP104620
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N5859_RS23355 Protein ID WP_249578050.1
Coordinates 2072..2359 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5859_RS23350 Protein ID WP_106693621.1
Coordinates 1824..2075 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS23340 (1) 1..858 + 858 WP_000130988.1 incFII family plasmid replication initiator RepA -
N5859_RS23345 (1560) 1560..1751 + 192 WP_072656942.1 hypothetical protein -
N5859_RS23350 (1824) 1824..2075 + 252 WP_106693621.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5859_RS23355 (2072) 2072..2359 + 288 WP_249578050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5859_RS23360 (2529) 2529..2933 + 405 WP_000154256.1 DUF2251 domain-containing protein -
N5859_RS23365 (3088) 3088..3468 + 381 WP_001171554.1 transposase -
N5859_RS23370 (3465) 3465..3730 + 266 Protein_6 IS66 family insertion sequence element accessory protein TnpB -
N5859_RS23375 (3861) 3861..5399 + 1539 WP_106693623.1 IS66-like element ISEc8 family transposase -
N5859_RS23380 (5511) 5511..5846 - 336 WP_021531026.1 colicin E1 family microcin immunity protein -
N5859_RS23385 (5975) 5975..6322 + 348 WP_000142443.1 DUF6404 family protein -
N5859_RS23390 (6340) 6340..6930 - 591 WP_045133249.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - afaC-I 1..89710 89710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11148.17 Da        Isoelectric Point: 10.3849

>T258645 WP_249578050.1 NZ_CP104620:2072-2359 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVEKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9201.38 Da        Isoelectric Point: 4.0780

>AT258645 WP_106693621.1 NZ_CP104620:1824-2075 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQSLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References