Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 2263640..2264123 Replicon chromosome
Accession NC_016785
Organism Corynebacterium diphtheriae CDCE 8392

Toxin (Protein)


Gene name relE Uniprot ID A0A6J4WN23
Locus tag CDCE8392_RS10615 Protein ID WP_014307502.1
Coordinates 2263640..2263909 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A6J4WZ27
Locus tag CDCE8392_RS12125 Protein ID WP_014307503.1
Coordinates 2263890..2264123 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCE8392_RS10595 2258840..2259556 - 717 WP_014307498.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CDCE8392_RS10600 2259609..2260634 - 1026 WP_014307499.1 type IV toxin-antitoxin system AbiEi family antitoxin -
CDCE8392_RS10605 2260656..2260970 - 315 WP_014307500.1 ATP-binding cassette domain-containing protein -
CDCE8392_RS10610 2261440..2263251 + 1812 WP_014307501.1 N-acetylmuramoyl-L-alanine amidase -
CDCE8392_RS10615 2263640..2263909 - 270 WP_014307502.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDCE8392_RS12125 2263890..2264123 - 234 WP_014307503.1 ribbon-helix-helix protein, CopG family Antitoxin
CDCE8392_RS10630 2264861..2265460 - 600 WP_014307505.1 RloB family protein -
CDCE8392_RS10635 2265488..2266819 - 1332 WP_014307506.1 ATP-binding protein -
CDCE8392_RS10640 2266914..2267504 - 591 WP_080572207.1 restriction endonuclease subunit S -
CDCE8392_RS10645 2267414..2267668 - 255 WP_014307508.1 hypothetical protein -
CDCE8392_RS10650 2267876..2268136 - 261 WP_014304055.1 hypothetical protein -
CDCE8392_RS10655 2268243..2269040 - 798 WP_014307509.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2261497..2288797 27300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10338.92 Da        Isoelectric Point: 10.6099

>T25864 WP_014307502.1 NC_016785:c2263909-2263640 [Corynebacterium diphtheriae CDCE 8392]
VTSWTIEFSPRAAKELRKLDRPVQKRIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVIVVVSI
GHRSQVYED

Download         Length: 270 bp

>T25864 NC_016785:c2263909-2263640 [Corynebacterium diphtheriae CDCE 8392]
GTGACCTCTTGGACGATTGAGTTTTCTCCGCGTGCTGCTAAAGAGCTCCGGAAGCTTGACCGGCCAGTTCAAAAGCGCAT
TGTTGCGTATCTTCGAGAAATCTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGGTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCGTTGCAGCTATTGAAGATGATCGTGTTGTCATCGTTGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9002.99 Da        Isoelectric Point: 4.3904

>AT25864 WP_014307503.1 NC_016785:c2264123-2263890 [Corynebacterium diphtheriae CDCE 8392]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETINLDEVERDLLDD

Download         Length: 234 bp

>AT25864 NC_016785:c2264123-2263890 [Corynebacterium diphtheriae CDCE 8392]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGGTCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAACTTGGACGAGGTAGAGCGTGACCTCTTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6J4WN23

Antitoxin

Source ID Structure
AlphaFold DB A0A6J4WZ27

References