Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3388334..3388952 Replicon chromosome
Accession NZ_CP104618
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5859_RS16550 Protein ID WP_001291435.1
Coordinates 3388734..3388952 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5859_RS16545 Protein ID WP_000344800.1
Coordinates 3388334..3388708 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS16535 (3383423) 3383423..3384616 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5859_RS16540 (3384639) 3384639..3387788 + 3150 WP_284632658.1 efflux RND transporter permease AcrB -
N5859_RS16545 (3388334) 3388334..3388708 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5859_RS16550 (3388734) 3388734..3388952 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5859_RS16555 (3389124) 3389124..3389675 + 552 WP_000102564.1 maltose O-acetyltransferase -
N5859_RS16560 (3389791) 3389791..3390261 + 471 WP_000136192.1 YlaC family protein -
N5859_RS16565 (3390425) 3390425..3391975 + 1551 WP_023281027.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5859_RS16570 (3392017) 3392017..3392370 - 354 WP_124846190.1 DUF1428 domain-containing protein -
N5859_RS16580 (3392749) 3392749..3393060 + 312 WP_000409911.1 MGMT family protein -
N5859_RS16585 (3393091) 3393091..3393663 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258637 WP_001291435.1 NZ_CP104618:3388734-3388952 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258637 WP_000344800.1 NZ_CP104618:3388334-3388708 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References