Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2401761..2402399 Replicon chromosome
Accession NZ_CP104618
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5859_RS11705 Protein ID WP_000813794.1
Coordinates 2402223..2402399 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5859_RS11700 Protein ID WP_105966292.1
Coordinates 2401761..2402177 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS11680 (2396913) 2396913..2397854 - 942 WP_001251319.1 ABC transporter permease -
N5859_RS11685 (2397855) 2397855..2398868 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
N5859_RS11690 (2398886) 2398886..2400031 - 1146 WP_124846286.1 ABC transporter substrate-binding protein -
N5859_RS11695 (2400276) 2400276..2401682 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N5859_RS11700 (2401761) 2401761..2402177 - 417 WP_105966292.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5859_RS11705 (2402223) 2402223..2402399 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5859_RS11710 (2402621) 2402621..2402851 + 231 WP_000494244.1 YncJ family protein -
N5859_RS11715 (2402943) 2402943..2404904 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5859_RS11720 (2404977) 2404977..2405513 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N5859_RS11725 (2405605) 2405605..2406780 + 1176 WP_032253412.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-67)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258636 WP_000813794.1 NZ_CP104618:c2402399-2402223 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15228.60 Da        Isoelectric Point: 4.7386

>AT258636 WP_105966292.1 NZ_CP104618:c2402177-2401761 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVIV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References