Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 4372666..4373297 | Replicon | chromosome |
Accession | NZ_CP104613 | ||
Organism | Escherichia coli strain AHM8C212RI |
Toxin (Protein)
Gene name | hicA | Uniprot ID | U9Y2A7 |
Locus tag | N5856_RS21170 | Protein ID | WP_001259385.1 |
Coordinates | 4373022..4373297 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | N5856_RS21165 | Protein ID | WP_000593555.1 |
Coordinates | 4372666..4373025 (-) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5856_RS21140 (4368798) | 4368798..4369742 | + | 945 | WP_000947062.1 | nickel ABC transporter permease subunit NikB | - |
N5856_RS21145 (4369739) | 4369739..4370572 | + | 834 | WP_001008963.1 | nickel ABC transporter permease subunit NikC | - |
N5856_RS21150 (4370572) | 4370572..4371336 | + | 765 | WP_001136236.1 | nickel import ATP-binding protein NikD | - |
N5856_RS21155 (4371333) | 4371333..4372139 | + | 807 | WP_000173666.1 | nickel import ATP-binding protein NikE | - |
N5856_RS21160 (4372145) | 4372145..4372546 | + | 402 | WP_001190062.1 | nickel-responsive transcriptional regulator NikR | - |
N5856_RS21165 (4372666) | 4372666..4373025 | - | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
N5856_RS21170 (4373022) | 4373022..4373297 | - | 276 | WP_001259385.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
N5856_RS21175 (4373370) | 4373370..4374494 | - | 1125 | WP_001314210.1 | ABC transporter permease | - |
N5856_RS21180 (4374494) | 4374494..4377229 | - | 2736 | WP_085008733.1 | ribosome-associated ATPase/putative transporter RbbA | - |
N5856_RS21185 (4377226) | 4377226..4378293 | - | 1068 | WP_097702179.1 | HlyD family secretion protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P7TTW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |