Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4372666..4373297 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag N5856_RS21170 Protein ID WP_001259385.1
Coordinates 4373022..4373297 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N5856_RS21165 Protein ID WP_000593555.1
Coordinates 4372666..4373025 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS21140 (4368798) 4368798..4369742 + 945 WP_000947062.1 nickel ABC transporter permease subunit NikB -
N5856_RS21145 (4369739) 4369739..4370572 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N5856_RS21150 (4370572) 4370572..4371336 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N5856_RS21155 (4371333) 4371333..4372139 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
N5856_RS21160 (4372145) 4372145..4372546 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N5856_RS21165 (4372666) 4372666..4373025 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5856_RS21170 (4373022) 4373022..4373297 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
N5856_RS21175 (4373370) 4373370..4374494 - 1125 WP_001314210.1 ABC transporter permease -
N5856_RS21180 (4374494) 4374494..4377229 - 2736 WP_085008733.1 ribosome-associated ATPase/putative transporter RbbA -
N5856_RS21185 (4377226) 4377226..4378293 - 1068 WP_097702179.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T258619 WP_001259385.1 NZ_CP104613:c4373297-4373022 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258619 WP_000593555.1 NZ_CP104613:c4373025-4372666 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References