Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4301988..4302742 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag N5856_RS20820 Protein ID WP_094317974.1
Coordinates 4302257..4302742 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag N5856_RS20815 Protein ID WP_000801912.1
Coordinates 4301988..4302266 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS20810 (4299216) 4299216..4301921 + 2706 WP_023486406.1 HTH-type transcriptional regulator MalT -
N5856_RS20815 (4301988) 4301988..4302266 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
N5856_RS20820 (4302257) 4302257..4302742 + 486 WP_094317974.1 GNAT family N-acetyltransferase Toxin
N5856_RS20825 (4302792) 4302792..4303820 - 1029 WP_094317992.1 RNA 3'-terminal phosphate cyclase -
N5856_RS20830 (4303824) 4303824..4305050 - 1227 WP_094317975.1 RNA-splicing ligase RtcB -
N5856_RS20835 (4305237) 4305237..4306835 + 1599 WP_001232937.1 DNA-binding transcriptional regulator RtcR -
N5856_RS20840 (4306817) 4306817..4307575 - 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17708.61 Da        Isoelectric Point: 9.1189

>T258617 WP_094317974.1 NZ_CP104613:4302257-4302742 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLEIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT258617 WP_000801912.1 NZ_CP104613:4301988-4302266 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References