Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3641046..3641700 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N5856_RS17570 Protein ID WP_000244781.1
Coordinates 3641046..3641453 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5856_RS17575 Protein ID WP_000354046.1
Coordinates 3641434..3641700 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS17550 (3637003) 3637003..3638736 - 1734 WP_094318021.1 single-stranded-DNA-specific exonuclease RecJ -
N5856_RS17555 (3638742) 3638742..3639452 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5856_RS17560 (3639477) 3639477..3640373 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N5856_RS17565 (3640485) 3640485..3641006 + 522 WP_001613762.1 flavodoxin FldB -
N5856_RS17570 (3641046) 3641046..3641453 - 408 WP_000244781.1 protein YgfX Toxin
N5856_RS17575 (3641434) 3641434..3641700 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5856_RS17580 (3641943) 3641943..3642923 + 981 WP_001613766.1 tRNA-modifying protein YgfZ -
N5856_RS17585 (3643000) 3643000..3643659 - 660 WP_000250274.1 hemolysin III family protein -
N5856_RS17590 (3643823) 3643823..3644134 - 312 WP_250308304.1 N(4)-acetylcytidine aminohydrolase -
N5856_RS17595 (3644179) 3644179..3645612 + 1434 WP_024250004.1 6-phospho-beta-glucosidase BglA -
N5856_RS17600 (3645669) 3645669..3646412 - 744 WP_085008381.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T258613 WP_000244781.1 NZ_CP104613:c3641453-3641046 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258613 WP_000354046.1 NZ_CP104613:c3641700-3641434 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References