Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3227378..3228003 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5856_RS15625 Protein ID WP_000911330.1
Coordinates 3227378..3227776 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N5856_RS15630 Protein ID WP_000450524.1
Coordinates 3227776..3228003 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS15605 (3223256) 3223256..3223456 + 201 WP_000383836.1 YpfN family protein -
N5856_RS15610 (3223566) 3223566..3224264 - 699 WP_000679823.1 esterase -
N5856_RS15615 (3224338) 3224338..3226353 - 2016 WP_097702170.1 tRNA cytosine(34) acetyltransferase TmcA -
N5856_RS15620 (3226368) 3226368..3227231 - 864 WP_001267498.1 neutral zinc metallopeptidase -
N5856_RS15625 (3227378) 3227378..3227776 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N5856_RS15630 (3227776) 3227776..3228003 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5856_RS15635 (3228157) 3228157..3228870 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N5856_RS15640 (3229083) 3229083..3230117 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N5856_RS15645 (3230134) 3230134..3231012 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N5856_RS15650 (3231158) 3231158..3231730 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N5856_RS15655 (3231730) 3231730..3232200 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T258610 WP_000911330.1 NZ_CP104613:c3227776-3227378 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT258610 WP_000450524.1 NZ_CP104613:c3228003-3227776 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References