Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2169545..2171133 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5856_RS10360 Protein ID WP_033815613.1
Coordinates 2169545..2170867 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5856_RS10365 Protein ID WP_250308169.1
Coordinates 2170867..2171133 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS10345 (2166937) 2166937..2167647 - 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -
N5856_RS10350 (2168008) 2168008..2168571 - 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
N5856_RS10355 (2169005) 2169005..2169280 - 276 Protein_2020 AraC family transcriptional regulator -
N5856_RS10360 (2169545) 2169545..2170867 - 1323 WP_033815613.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
N5856_RS10365 (2170867) 2170867..2171133 - 267 WP_250308169.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5856_RS10370 (2171222) 2171222..2174156 - 2935 Protein_2023 ESPR-type extended signal peptide-containing protein -
N5856_RS10375 (2174687) 2174687..2175256 - 570 Protein_2024 FGGY-family carbohydrate kinase -
N5856_RS10380 (2175255) 2175255..2175515 + 261 Protein_2025 autoinducer 2 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49334.97 Da        Isoelectric Point: 8.5823

>T258605 WP_033815613.1 NZ_CP104613:c2170867-2169545 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10061.42 Da        Isoelectric Point: 6.2446

>AT258605 WP_250308169.1 NZ_CP104613:c2171133-2170867 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TERQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References