Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1708242..1709082 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag N5856_RS08095 Protein ID WP_000854686.1
Coordinates 1708699..1709082 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0YJ34
Locus tag N5856_RS08090 Protein ID WP_001360163.1
Coordinates 1708242..1708622 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS08065 (1705358) 1705358..1706176 + 819 WP_001234732.1 DUF932 domain-containing protein -
N5856_RS08070 (1706268) 1706268..1706753 + 486 WP_000214307.1 antirestriction protein -
N5856_RS08075 (1706769) 1706769..1707245 + 477 WP_001186726.1 RadC family protein -
N5856_RS08080 (1707308) 1707308..1707529 + 222 WP_000692298.1 DUF987 domain-containing protein -
N5856_RS08085 (1707548) 1707548..1708231 + 684 WP_000086769.1 hypothetical protein -
N5856_RS08090 (1708242) 1708242..1708622 + 381 WP_001360163.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N5856_RS08095 (1708699) 1708699..1709082 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
N5856_RS08100 (1709079) 1709079..1709567 + 489 WP_001054233.1 DUF5983 family protein -
N5856_RS08105 (1709584) 1709584..1709697 + 114 Protein_1574 DUF957 domain-containing protein -
N5856_RS08110 (1709695) 1709695..1710183 + 489 Protein_1575 DUF4942 domain-containing protein -
N5856_RS08120 (1710654) 1710654..1711592 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
N5856_RS08125 (1711647) 1711647..1712384 + 738 WP_000283664.1 zinc-binding phosphatase -
N5856_RS08130 (1712408) 1712408..1712962 + 555 WP_001001917.1 molecular chaperone YcdY -
N5856_RS08135 (1713064) 1713064..1713555 + 492 WP_001383029.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T258603 WP_000854686.1 NZ_CP104613:1708699-1709082 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13950.74 Da        Isoelectric Point: 5.0823

>AT258603 WP_001360163.1 NZ_CP104613:1708242-1708622 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0YJ34

References