Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1096746..1097364 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5856_RS05240 Protein ID WP_001291435.1
Coordinates 1096746..1096964 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag N5856_RS05245 Protein ID WP_250308268.1
Coordinates 1096990..1097364 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS05205 (1092035) 1092035..1092607 + 573 WP_000779831.1 YbaY family lipoprotein -
N5856_RS05210 (1092638) 1092638..1092949 - 312 WP_000409911.1 MGMT family protein -
N5856_RS05220 (1093328) 1093328..1093681 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5856_RS05225 (1093723) 1093723..1095273 - 1551 WP_024210825.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5856_RS05230 (1095437) 1095437..1095907 - 471 WP_033814868.1 YlaC family protein -
N5856_RS05235 (1096023) 1096023..1096574 - 552 WP_094317739.1 maltose O-acetyltransferase -
N5856_RS05240 (1096746) 1096746..1096964 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5856_RS05245 (1096990) 1096990..1097364 - 375 WP_250308268.1 Hha toxicity modulator TomB Antitoxin
N5856_RS05250 (1097910) 1097910..1101059 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5856_RS05255 (1101082) 1101082..1102275 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258602 WP_001291435.1 NZ_CP104613:c1096964-1096746 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14545.33 Da        Isoelectric Point: 4.7395

>AT258602 WP_250308268.1 NZ_CP104613:c1097364-1096990 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKTKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References