Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 609401..609951 | Replicon | chromosome |
Accession | NZ_CP104613 | ||
Organism | Escherichia coli strain AHM8C212RI |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | Q32K46 |
Locus tag | N5856_RS02945 | Protein ID | WP_001160974.1 |
Coordinates | 609637..609951 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | N5856_RS02940 | Protein ID | WP_000125566.1 |
Coordinates | 609401..609634 (+) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5856_RS02915 (604472) | 604472..604759 | + | 288 | WP_000203747.1 | ferredoxin-like protein FixX | - |
N5856_RS02920 (604817) | 604817..606148 | + | 1332 | WP_074526432.1 | MFS transporter | - |
N5856_RS02925 (606259) | 606259..606789 | + | 531 | WP_000600718.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
N5856_RS02930 (606782) | 606782..608644 | + | 1863 | WP_284632345.1 | glutathione-regulated potassium-efflux system protein KefC | - |
N5856_RS02935 (608836) | 608836..609315 | + | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
N5856_RS02940 (609401) | 609401..609634 | + | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
N5856_RS02945 (609637) | 609637..609951 | + | 315 | WP_001160974.1 | CcdB family protein | Toxin |
N5856_RS02950 (609948) | 609948..610796 | - | 849 | WP_069913600.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
N5856_RS02955 (610803) | 610803..611180 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
N5856_RS02960 (611183) | 611183..612004 | - | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
N5856_RS02965 (612001) | 612001..612990 | - | 990 | WP_069913599.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
N5856_RS02970 (612990) | 612990..614276 | - | 1287 | WP_000800453.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11737.84 Da Isoelectric Point: 9.8517
>T258600 WP_001160974.1 NZ_CP104613:609637-609951 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFIRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFIRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LRR3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |