Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 492218..492794 Replicon chromosome
Accession NZ_CP104613
Organism Escherichia coli strain AHM8C212RI

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag N5856_RS02375 Protein ID WP_094317815.1
Coordinates 492218..492505 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag N5856_RS02380 Protein ID WP_000063156.1
Coordinates 492492..492794 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5856_RS02360 (487797) 487797..489182 - 1386 WP_094317814.1 restriction endonuclease subunit S -
N5856_RS02365 (489172) 489172..490791 - 1620 WP_001672353.1 class I SAM-dependent DNA methyltransferase -
N5856_RS02370 (490855) 490855..492021 - 1167 WP_000800829.1 restriction endonuclease -
N5856_RS02375 (492218) 492218..492505 + 288 WP_094317815.1 BrnT family toxin Toxin
N5856_RS02380 (492492) 492492..492794 + 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
N5856_RS02385 (492828) 492828..493784 - 957 WP_001295525.1 GTPase -
N5856_RS02390 (493795) 493795..493998 - 204 WP_000467859.1 YbdD/YjiX family protein -
N5856_RS02395 (494129) 494129..496279 - 2151 WP_001298933.1 pyruvate/proton symporter BtsT -
N5856_RS02400 (496672) 496672..497184 - 513 WP_001175455.1 4-hydroxyphenylacetate 3-monooxygenase reductase subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11183.65 Da        Isoelectric Point: 7.4697

>T258599 WP_094317815.1 NZ_CP104613:492218-492505 [Escherichia coli]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT258599 WP_000063156.1 NZ_CP104613:492492-492794 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References