Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 2729..3321 | Replicon | plasmid pHNAH8161B-5 |
Accession | NZ_CP104609 | ||
Organism | Klebsiella pneumoniae strain AHM8C161BI |
Toxin (Protein)
Gene name | hicA | Uniprot ID | V0AGQ2 |
Locus tag | N5862_RS30730 | Protein ID | WP_000520549.1 |
Coordinates | 2729..2977 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | V0AWG0 |
Locus tag | N5862_RS30735 | Protein ID | WP_000681613.1 |
Coordinates | 2974..3321 (+) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5862_RS30705 (N5862_30695) | 226..768 | + | 543 | WP_001083906.1 | hypothetical protein | - |
N5862_RS30710 (N5862_30700) | 765..1016 | + | 252 | WP_001230707.1 | hypothetical protein | - |
N5862_RS30715 (N5862_30705) | 1003..1230 | + | 228 | WP_000801440.1 | hypothetical protein | - |
N5862_RS30720 (N5862_30710) | 1684..1983 | + | 300 | WP_000650309.1 | hypothetical protein | - |
N5862_RS30725 (N5862_30715) | 2074..2424 | + | 351 | WP_000854259.1 | hypothetical protein | - |
N5862_RS30730 (N5862_30720) | 2729..2977 | + | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
N5862_RS30735 (N5862_30725) | 2974..3321 | + | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
N5862_RS30740 (N5862_30730) | 3682..4185 | + | 504 | WP_000781813.1 | relaxosome-coupling protein TaxA | - |
N5862_RS30745 (N5862_30735) | 4189..5418 | + | 1230 | WP_001329504.1 | DNA relaxase/nickase TaxC | - |
N5862_RS30750 (N5862_30740) | 5495..5788 | + | 294 | WP_060598542.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
N5862_RS30755 (N5862_30745) | 5785..6000 | + | 216 | WP_000760375.1 | EexN family lipoprotein | - |
N5862_RS30760 (N5862_30750) | 6356..6976 | + | 621 | WP_000157549.1 | lytic transglycosylase domain-containing protein | - |
N5862_RS30765 (N5862_30755) | 6990..7316 | + | 327 | WP_000008647.1 | TrbC/VirB2 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..33310 | 33310 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CIX3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CLC1 |