Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 765..1230 Replicon plasmid pHNAH8161B-5
Accession NZ_CP104609
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag N5862_RS30710 Protein ID WP_001230707.1
Coordinates 765..1016 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag N5862_RS30715 Protein ID WP_000801440.1
Coordinates 1003..1230 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS30705 (N5862_30695) 226..768 + 543 WP_001083906.1 hypothetical protein -
N5862_RS30710 (N5862_30700) 765..1016 + 252 WP_001230707.1 hypothetical protein Toxin
N5862_RS30715 (N5862_30705) 1003..1230 + 228 WP_000801440.1 hypothetical protein Antitoxin
N5862_RS30720 (N5862_30710) 1684..1983 + 300 WP_000650309.1 hypothetical protein -
N5862_RS30725 (N5862_30715) 2074..2424 + 351 WP_000854259.1 hypothetical protein -
N5862_RS30730 (N5862_30720) 2729..2977 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
N5862_RS30735 (N5862_30725) 2974..3321 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
N5862_RS30740 (N5862_30730) 3682..4185 + 504 WP_000781813.1 relaxosome-coupling protein TaxA -
N5862_RS30745 (N5862_30735) 4189..5418 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
N5862_RS30750 (N5862_30740) 5495..5788 + 294 WP_060598542.1 sigma factor-like helix-turn-helix DNA-binding protein -
N5862_RS30755 (N5862_30745) 5785..6000 + 216 WP_000760375.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33310 33310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T258595 WP_001230707.1 NZ_CP104609:765-1016 [Klebsiella pneumoniae]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT258595 WP_000801440.1 NZ_CP104609:1003-1230 [Klebsiella pneumoniae]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References