258594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11123..11766 Replicon plasmid pHNAH8161B-4
Accession NZ_CP104608
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag N5862_RS30580 Protein ID WP_000754566.1
Coordinates 11350..11766 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag N5862_RS30575 Protein ID WP_001261276.1
Coordinates 11123..11353 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS30540 (N5862_30530) 6242..6511 + 270 WP_000339857.1 hypothetical protein -
N5862_RS30545 (N5862_30535) 6688..7554 - 867 WP_004118283.1 replication initiation protein -
N5862_RS30550 (N5862_30540) 8084..8188 + 105 WP_032409716.1 hypothetical protein -
N5862_RS30555 (N5862_30545) 8317..8574 + 258 WP_000764642.1 hypothetical protein -
N5862_RS30560 (N5862_30550) 8632..9408 - 777 WP_000015958.1 site-specific integrase -
N5862_RS30565 (N5862_30555) 9405..10148 - 744 WP_000129823.1 hypothetical protein -
N5862_RS30570 (N5862_30560) 10199..10549 - 351 WP_000493378.1 hypothetical protein -
N5862_RS30575 (N5862_30565) 11123..11353 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N5862_RS30580 (N5862_30570) 11350..11766 + 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
N5862_RS30585 (N5862_30575) 11970..12655 + 686 Protein_14 IS3-like element ISEc15 family transposase -
N5862_RS30590 (N5862_30580) 13328..14836 + 1509 WP_001189123.1 group II intron reverse transcriptase/maturase -
N5862_RS30595 (N5862_30585) 14917..15096 + 180 Protein_16 DDE-type integrase/transposase/recombinase -
N5862_RS30600 (N5862_30590) 15378..16454 + 1077 WP_000227969.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-Ib-cr / qacE / sul1 - 1..36052 36052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T258594 WP_000754566.1 NZ_CP104608:11350-11766 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT258594 WP_001261276.1 NZ_CP104608:11123-11353 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References