Detailed information of TA system TA025859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2258754..2259237
• Replicon: chromosome
• Accession: NC_016783
• Organism: Corynebacterium diphtheriae INCA 402

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CDB402_RS10560
• Protein ID: WP_044026353.1
• Coordinates: 2258754..2259023 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CDB402_RS12100
• Protein ID: WP_014304050.1
• Coordinates: 2259004..2259237 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDB402_RS10535	2253979..2254695	-	717	WP_014304046.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
CDB402_RS10540	2254748..2255773	-	1026	WP_014304047.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
CDB402_RS10545	2255835..2256110	-	276	WP_014304048.1	ATP-binding cassette domain-containing protein	-
CDB402_RS10550	2256580..2258391	+	1812	WP_014304049.1	N-acetylmuramoyl-L-alanine amidase	-
CDB402_RS10560	2258754..2259023	-	270	WP_044026353.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDB402_RS12100	2259004..2259237	-	234	WP_014304050.1	ribbon-helix-helix protein, CopG family	Antitoxin
CDB402_RS10570	2259484..2259852	+	369	WP_014304051.1	transposase	-
CDB402_RS12535	2260111..2260284	+	174	WP_158307795.1	hypothetical protein	-
CDB402_RS10575	2260488..2261088	-	601	Protein_2057	RloB domain-containing protein	-
CDB402_RS10580	2261115..2262446	-	1332	WP_014304053.1	ATP-binding protein	-
CDB402_RS12435	2262521..2263038	-	518	Protein_2059	restriction endonuclease subunit S	-
CDB402_RS10590	2263375..2263635	-	261	WP_014304055.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2256637..2283570	26933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10423.08 Da
• Isoelectric Point: 10.6099

>T25859 WP_044026353.1 NC_016783:c2259023-2258754 [Corynebacterium diphtheriae INCA 402]
VTSWTIEFSPRAAKELRKLDRPVQKRIVAYLREISTLPNPQMRGKALTGNWAVFWRWRVGDYRLIVAIEDDRVVIVVVSI
GHRSQVYED

Nucleotide

• Length: 270 bp

>T25859 NC_016783:c2259023-2258754 [Corynebacterium diphtheriae INCA 402]
GTGACCTCTTGGACGATTGAGTTTTCTCCGCGTGCTGCTAAAGAGCTCCGGAAGCTTGACCGGCCAGTTCAAAAGCGCAT
TGTTGCGTATCTTCGAGAAATCTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGTTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCATTGTAGCTATTGAAGATGATCGTGTTGTCATCGTTGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8975.96 Da
• Isoelectric Point: 4.3904

>AT25859 WP_014304050.1 NC_016783:c2259237-2259004 [Corynebacterium diphtheriae INCA 402]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETISLDEVERDLLDD

Nucleotide

• Length: 234 bp

>AT25859 NC_016783:c2259237-2259004 [Corynebacterium diphtheriae INCA 402]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGATCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAGCTTGGACGAGGTAGAGCGTGACCTCTTGGACGATTGA