258588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 227597..228119 Replicon plasmid pHNAH8161B-1
Accession NZ_CP104604
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag N5862_RS27300 Protein ID WP_004181778.1
Coordinates 227835..228119 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag N5862_RS27295 Protein ID WP_004181777.1
Coordinates 227597..227845 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS27275 (N5862_27265) 222806..223627 - 822 WP_004181772.1 hypothetical protein -
N5862_RS27280 (N5862_27270) 223689..224042 - 354 WP_004181774.1 hypothetical protein -
N5862_RS27285 (N5862_27275) 224187..225173 - 987 WP_025368599.1 hypothetical protein -
N5862_RS27290 (N5862_27280) 225507..227306 - 1800 WP_004181776.1 ATP-dependent helicase -
N5862_RS27295 (N5862_27285) 227597..227845 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N5862_RS27300 (N5862_27290) 227835..228119 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5862_RS27305 (N5862_27295) 228136..228225 - 90 Protein_243 IS200/IS605 family transposase -
N5862_RS27310 (N5862_27300) 228271..229497 + 1227 WP_284652934.1 transposase -
N5862_RS27315 (N5862_27305) 229768..229992 - 225 Protein_245 transposase -
N5862_RS27320 (N5862_27310) 230071..230499 - 429 WP_284653137.1 IS200/IS605 family transposase -
N5862_RS27325 (N5862_27315) 230535..231722 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
N5862_RS27330 (N5862_27320) 231767..232138 - 372 WP_040209644.1 hypothetical protein -
N5862_RS27335 (N5862_27325) 232135..232479 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / blaDHA-1 / qnrB4 / armA / msr(E) / mph(E) / aph(3')-Ia / ant(2'')-Ia / blaCTX-M-15 / qnrS1 - 1..315605 315605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T258588 WP_004181778.1 NZ_CP104604:227835-228119 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT258588 WP_004181777.1 NZ_CP104604:227597-227845 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References