Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 154289..155040 Replicon plasmid pHNAH8161B-1
Accession NZ_CP104604
Organism Klebsiella pneumoniae strain AHM8C161BI

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag N5862_RS26895 Protein ID WP_014386536.1
Coordinates 154289..154771 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag N5862_RS26900 Protein ID WP_004902250.1
Coordinates 154762..155040 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5862_RS26875 (N5862_26865) 150688..151335 - 648 WP_014386537.1 EcsC family protein -
N5862_RS26880 (N5862_26870) 151362..152117 - 756 WP_004902235.1 DUF2971 domain-containing protein -
N5862_RS26885 (N5862_26875) 152218..152610 - 393 WP_032442757.1 hypothetical protein -
N5862_RS26890 (N5862_26880) 152715..153254 - 540 WP_004902239.1 hypothetical protein -
N5862_RS26895 (N5862_26885) 154289..154771 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
N5862_RS26900 (N5862_26890) 154762..155040 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
N5862_RS26905 (N5862_26895) 155159..155371 - 213 WP_004902255.1 hypothetical protein -
N5862_RS26910 (N5862_26900) 155479..155820 - 342 WP_004902257.1 hypothetical protein -
N5862_RS26915 (N5862_26905) 156740..158038 - 1299 Protein_165 Tn3-like element Tn3 family transposase -
N5862_RS26920 (N5862_26910) 158106..158810 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
N5862_RS26925 (N5862_26915) 159004..159390 + 387 WP_063102497.1 bleomycin binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / blaDHA-1 / qnrB4 / armA / msr(E) / mph(E) / aph(3')-Ia / ant(2'')-Ia / blaCTX-M-15 / qnrS1 - 1..315605 315605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T258587 WP_014386536.1 NZ_CP104604:c154771-154289 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT258587 WP_004902250.1 NZ_CP104604:c155040-154762 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References