Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 37616..38526 | Replicon | plasmid pHNAH8161B-1 |
| Accession | NZ_CP104604 | ||
| Organism | Klebsiella pneumoniae strain AHM8C161BI | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | N5862_RS26340 | Protein ID | WP_004181896.1 |
| Coordinates | 38056..38526 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | N5862_RS26335 | Protein ID | WP_004181895.1 |
| Coordinates | 37616..38059 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5862_RS26310 (N5862_26300) | 32771..32986 | - | 216 | Protein_44 | IS200/IS605 family transposase | - |
| N5862_RS26315 (N5862_26305) | 32988..33557 | + | 570 | Protein_45 | transposase | - |
| N5862_RS26320 (N5862_26310) | 34249..35736 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| N5862_RS26325 (N5862_26315) | 35822..36244 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| N5862_RS26330 (N5862_26320) | 36244..37515 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| N5862_RS26335 (N5862_26325) | 37616..38059 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| N5862_RS26340 (N5862_26330) | 38056..38526 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| N5862_RS26345 (N5862_26335) | 38636..38896 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| N5862_RS26350 (N5862_26340) | 39619..39777 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| N5862_RS26355 (N5862_26345) | 40380..41354 | + | 975 | WP_004181899.1 | hypothetical protein | - |
| N5862_RS26360 (N5862_26350) | 41552..41929 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / blaDHA-1 / qnrB4 / armA / msr(E) / mph(E) / aph(3')-Ia / ant(2'')-Ia / blaCTX-M-15 / qnrS1 | - | 1..315605 | 315605 | |
| - | flank | IS/Tn | - | - | 33171..33557 | 386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T258585 WP_004181896.1 NZ_CP104604:38056-38526 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT258585 WP_004181895.1 NZ_CP104604:37616-38059 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |